Formulation: A solid
Formal Name: N-[[(5S)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide-d3
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C16H17D3FN3O4
Formula Weight: 340,4
Shelf life (days): 1460
CAS Number: 1127120-38-0
Notes: Linezolid-d3 is intended for use as an internal standard for the quantification of linezolid (Item No. 15012) by GC- or LC-MS. Linezolid is a synthetic oxazolidinone antibiotic with activity against a wide range of Gram-positive bacteria, including resistant strains of several species, such as methicillin-resistant S. aureus (MRSA), penicillin-resistant pneumococci, vancomycin-resistant enterococci, various anaerobic bacteria, and several mycobacteria and streptococci (MICs = 2-4 mg/ml).{22653} Linezolid inhibits protein synthesis by binding to domain V of the 23S ribosomal RNA of the 50S subunit of bacterial ribosomes. In vivo, linezolid (50 mg/kg) reduces pulmonary MRSA load in spontaneously breathing and mechanically ventilated rabbits.{36681} Formulations containing linezolid have been used to treat MRSA infections.
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