Formulation: A solid
Purity: ≥95%
Formula Markup: C12HCl7O
Formula Weight: 409,3
Shelf life (days): 1460
CAS Number: 55673-89-7
Notes: 1,2,3,4,7,8,9-Heptachlorodibenzofuran is a dioxin-like polychlorinated dibenzofuran (PCDF).{51293} It induces the expression of the genes encoding the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1B1, as well as the aryl hydrocarbon receptor repressor (AhRR) in primary human peripheral blood lymphocytes and increases ethoxyresorufin-O-deethylase (EROD) activity, a marker of CYP1A1 activity, in isolated human peripheral blood lymphocytes in a concentration-dependent manner. 1,2,3,4,7,8,9-Heptachlorodibenzofuran decreases the number of splenic plaque-forming cells, indicating immunosuppression, and increases hepatic microsomal aryl hydrocarbon hydroxylase (AHH) activity in mice induced with sheep red blood cells (ED50s = 12 and 700 nmol/kg, respectively).{49788} It has been found in human breastmilk and in the air near municipal waste incinerators.{69322,51294}
English
Deutsch
