Formulation: A solution in n-nonane
Formal Name: 1,2,3,7,8-pentachloro-dibenzo[b,e][1,4]dioxin
Purity: ≥98%
Formula Markup: C12H3Cl5O2
Formula Weight: 356,4
Shelf life (days): 730
CAS Number: 40321-76-4
Notes: 1,2,3,7,8-Pentachlorodibenzo-p-dioxin is a polychlorinated dibenzodioxin (PCDD).{51293} It induces the expression of the genes encoding the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1B1, as well as the aryl hydrocarbon receptor repressor (AhRR) in primary human peripheral blood lymphocytes and increases ethoxyresorufin-O-deethylase (EROD) activity, a marker of CYP1A1 activity, in isolated human peripheral blood lymphocytes in a concentration-dependent manner. 1,2,3,7,8-Pentachlorodibenzo-p-dioxin is toxic to female Han/Wistar rats with an LD50 value between 20 and 60 µg/kg, but is not toxic to female Long-Evans rats (LD50 = >1,620 µg/kg).{65679} It has been found in freshwater fish and animal feed, as well as in the air near municipal waste incinerators and in blood from individuals that lived near or in herbicide-sprayed regions.{69320,65680,51294,66374}
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