Formulation: A solid
Formal Name: 3-[3-(3,6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl]-2,4-thiazolidinedione
Purity: ≥98%
Formula Markup: C18H14Cl2N2O3S
Formula Weight: 409,3
Shelf life (days): 1460
CAS Number: 312631-87-1
Notes: 10074-A4 is an inhibitor of the protein-protein interaction between c-Myc and the c-Myc associated protein Max.{25765} It inhibits c-Myc and Max heterodimerization when used at a concentration of 5 µM and reduces the proliferation of Rat1 and TGR-1 rat fibroblasts but not TGR-1 Myc knockout fibroblasts at 32 µM. 10074-A4 (32 µM) reduces the expression of the gene encoding ornithine decarboxylase (ODC), a c-Myc and Max target gene, and induces cell cycle arrest at the G0/G1 phase in Myc-overexpressing Rat1 cells. Preincubation of 10074-A4 (32 µM) with Myc-overexpressing Rat1 cells in vitro reduces tumor growth of the same cells in a mouse xenograft model.
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