Formulation: A solid
Formal Name: estra-1,3,5(10)-triene-16,16,17-d3-3,17β-diol
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C18H21D3O2
Formula Weight: 275,4
Shelf life (days): 1460
CAS Number: 79037-37-9
Notes: 17β-Estradiol-d3 is intended for use as an internal standard for the quantification of 17β-estradiol (Item Nos. ISO60155 / 10006315). 17β-Estradiol is the major pre-menopausal bioactive estrogen and an active metabolite of testosterone.{68406,68407,68408} It is produced primarily by the ovary, and to a lesser extent, by the adrenals, testes, and adipose tissue, as well as by the placenta during pregnancy.{68406} 17β-Estradiol binds to estrogen receptors localized to the nucleus, cytoplasm, and plasma membrane and induces gene transcription or non-genomic intracellular signaling in a location-dependent manner.{68407} It regulates reproductive development in females and spermatogenesis in males, as well as various non-reproductive processes including lipid and glucose homeostasis, bone mass maintenance, cognition, energy balance, and dilation of blood vessels.{68407,68408} 17β-Estradiol deficiency due to hypogonadism or 17α-hydroxylase/17,20-lyase deficiency is associated with fatigue, incontinence, osteoporosis, depression, emotional instability, and hot flashes.
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