Formulation: A solid
Formal Name: 4-[[6-amino-7,8-dihydro-2-(2-methoxyethoxy)-8-oxo-9H-purin-9-yl]methyl]-benzoic acid
Purity: ≥98%
Formula Markup: C16H17N5O5
Formula Weight: 359,3
Shelf life (days): 1460
CAS Number: 1062444-54-5
Notes: 1V209 is a benzoic acid-modified purine that, when conjugated to polysaccharides or sterols, acts as a toll-like receptor 7 (TLR7) agonist.{69340,69341} A variety of 1V209-polysaccharide conjugates, but not 1V209 alone, increase TNF-α secretion from RAW 264.7 macrophages and IL-6 secretion from bone marrow-derived dendritic cells (BMDCs; EC50s = 4.62-61.7 and 3.2-188 nM, respectively). Liposomes encapsulating 1V209-cholesterol conjugates decrease primary tumor weight, secondary tumor volume, and the number of secondary lung metastases, as well as increase tumor-associated CD8+ IFN-γ+ T cells and survival, in a CT26 colorectal cancer mouse model of tumor rechallenge and lung metastasis.{69341}
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