Formulation: A solid
Formal Name: 2,3,7,8-tetrachloro-dibenzo[b,e][1,4]dioxin
Purity: ≥95%
Formula Markup: C12H4Cl4O2
Formula Weight: 322
Shelf life (days): 1460
CAS Number: 1746-01-6
Notes: 2,3,7,8-Tetrachlorodibenzo-p-dioxin is a toxicant and an agonist of the aryl hydrocarbon receptor (AhR; ED50 = 0.2 nmol/kg in a reporter assay using chicken embryos).{67284} It also induces AhR ubiquitination and degradation in Hepa-1c1c7 hepatic cells when used at a concentration of 1 nM.{67285} Oral administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (0.1 mg/kg) increases mortality and induces severe liver necrosis, thymic atrophy, and cell depletion in lymphoid organs in rats.{67286} It does not induce hepatomegaly or reduce thymus weight and lymphocyte number but does increase immune cell infiltration into the lungs in AhR knockout mice when administered at a dose of 2 mg/kg.{67287}
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