Formulation: A solution in water
Formal Name: 2′,3′-dideoxy-adenosine 5′-(tetrahydrogen triphosphate), tetrasodium salt
Purity: ≥95%
Formula Markup: C10H12N5O11P3 • 4Na
Formula Weight: 563,1
Shelf life (days): 730
CAS Number: 99827-72-2
Notes: 2',3'-Dideoxyadenosine-5'-O-triphosphate is a reverse transcriptase inhibitor (Kis = 20 and 37 nM for the HIV and visna virus enzymes, respectively) and an active metabolite of 2′,3′-dideoxyadenosine (ddA; Item No. 36662) and didanosine (ddI; Item No. 23715).{28262,28268,64902} It is formed from ddI via a 2',3'-dideoxyAMP intermediate by phosphoribosyl pyrophosphate synthase (PRS).{64902} It inhibits DNA polymerase isolated from mouse Ehrlich ascites tumor cells in the presence of ATP or GDP (Kis = 60 and 18 µM, respectively).{28263} 2',3'-Dideoxyadenosine-5'-O-triphosphate and other dideoxynucleoside 5'-triphosphates are commonly used to terminate chain extension by Taq polymerases in PCR assays.{28266}
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