Formulation: A solution in water
Formal Name: 2′,3′-dideoxy-guanosine, 5′→P′′-ester with thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(O)(OH)(SH)), tetrasodium salt
Purity: ≥95% (a mixture of Rp and Sp isomers)
Formula Markup: C10H12N5O11P3S • 4Na
Formula Weight: 595,2
Shelf life (days): 730
Notes: 2',3'-Dideoxyguanosine-5'-O-(1-thiotriphosphate) (ddGTP-α-S) is a sulfur-containing nucleoside triphosphate derivative. Thiol-containing dideoxynucleoside triphosphates (α-S-ddNTPs) incorporated into allele-specific primers prevent complete digestion by 5'-phosphodiesterase, which allows for alkylation and identification of SNP-containing alleles.{67351} ddGTP-α-S has been used for chain extension using a mutated polymerase selective for dideoxynucleotides and chain termination in allele-specific PCR assays.{51318,67351} ddGTP-α-S is a mixture of Rp and Sp isomers.
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