Formulation: A solution in water
Formal Name: 3′-deoxy-thymidine, 5′→P′′-ester with thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(O)(OH)(SH)), tetrasodium salt
Purity: ≥95% (a mixture of Rp and Sp isomers)
Formula Markup: C10H13N2O12P3S • 4Na
Formula Weight: 570,2
Shelf life (days): 730
Notes: 2',3'-Dideoxythymidine-5'-O-(1-thiotriphosphate) (ddTTP-α-S) is a sulfur-containing nucleoside triphosphate derivative. Thiol-containing dideoxynucleoside triphosphates (α-S-ddNTPs) incorporated into allele-specific primers prevent complete digestion by 5’-phosphodiesterase, which allows for alkylation and identification of SNP-containing alleles.{69342} ddTTP-α-S has been used for chain extension in PCR assays.{69343} ddTTP-α-S is a mixture of Rp and Sp isomers.