2'(3')-O-(N'-Methylanthraniloyl)guanosine-5'-O-triphosphate (sodium salt)

Formulation: A solution in water

Formal Name: 2′(or 3′)-[2-(methylamino)benzoate] guanosine 5′-(tetrahydrogen triphosphate), tetrasodium salt

Purity: ≥95% (mixture of isomers)

Formula Markup: C18H19N6O15P3 • 4Na

Formula Weight: 744,3

Shelf life (days): 730

Notes: 2'-O-(N-Methylanthraniloyl)guanosine-5'-O-triphosphate (2'-MANT-GTP) and 3'-MANT-GTP are fluorescent GTP derivatives, which undergo spontaneous isomerization.{65690} 2'(3')-MANT-GTP displays an emission maximum of 442 nm upon excitation at 350 nm.{67581} It inhibits mammalian adenylyl cyclase (AC1), AC2, and AC5 (Kis = 90, 610, and 53 nM, respectively), B. pertussis AC toxin CyaA (Kis = 5.9 and 16 µM, in the presence of manganese and magnesium, respectively), and B. anthracis AC toxin edema factor (Kis = 2.49 and 4.7 µM in the presence of manganese and magnesium, respectively).{65690,65691,65692}

• SKU: CAY38469
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 38469-3.3
• Green Labware: No
• Package Unit: 3,3 mg
• Quantity Unit: STK
• Application: Reinstoffe, Fluorescence