Formulation: A solution in water
Formal Name: 2-chloro-adenosine 5′-(trihydrogen diphosphate), trisodium salt
Purity: ≥95%
Formula Markup: C10H11ClN5O10P2 • 3Na
Formula Weight: 527,6
Shelf life (days): 730
CAS Number: 82927-78-4
Notes: 2-Chloroadenosine-5'-O-diphosphate is a derivative of the purine nucleotide adenosine 5'diphosphate (ADP; Item Nos. 16778 / 21121). It induces aggregation of, and inhibits the production of cyclic AMP (cAMP; Item No. 18820) induced by prostaglandin E2 (PGE2; Item No. 14010) in, isolated human platelet-rich plasma in a concentration-dependent manner.{68363} 2-Chloroadenosine-5'-O-diphosphate induces relaxation of precontracted isolated guinea pig taenia coli strips (pD2 = 6.74).{62566} It decreases arterial blood pressure in rats.{68364} 2-Chloroadenosine-5'-O-diphosphate also inhibits the ATPase activity of the heat shock protein 70 (Hsp70) family member mortalin (apparent Ki = 45.05 µM for the human enzyme).{69295}
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