2'-Deoxy-3'-O-(N'-methylanthraniloyl)guanosine-5'-O-triphosphate (sodium salt)

Formulation: A solution in water

Formal Name: 2′-deoxy-3′-[2-(methylamino)benzoate] guanosine 5′-(tetrahydrogen triphosphate), tetrasodium salt

Purity: ≥95%

Formula Markup: C18H19N6O14P3 • 4Na

Formula Weight: 728,3

Shelf life (days): 730

Notes: 2'-Deoxy-3'-O-(N'-methylanthraniloyl)guanosine-5'-O-triphosphate (2’-deoxy-3’-MANT-GTP) is a fluorescent derivative of dGTP (Item No. 35771).{67344,67345,67346} It selectively inhibits recombinant mammalian adenylyl cyclase 1 (AC1), AC2, AC5, and AC6 (Kis = 260, 1,200, 420, and 470 nM, respectively), bovine lung soluble guanylyl cyclase (sGC; Ki = 220 nM), and B. anthracis edema factor AC toxin (Ki = 630 nM) over rat testis soluble AC (sAC) and B. pertussis AC toxin (Kis = 43 and 14 µM, respectively).{67344} 2’-deoxy-3’-MANT-GTP has been used to study the activity of various GTPases, including elongation factor Tu (EF-Tu) and H-Ras p21.{67345,67346} A related derivative, 2'(3')-MANT-GTP (Item No. 38469), displays an emission maximum of 442 nm upon excitation at 350 nm.{67581}

• SKU: CAY38459
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 38459-3.2
• Green Labware: No
• Package Unit: 3,2 mg
• Quantity Unit: STK
• Application: Reinstoffe, Fluorescence