Formulation: A solid
Formal Name: 2-hydroxy-4-methyl-pentanoic acid
Purity: ≥98%
Formula Markup: C6H12O3
Formula Weight: 132,2
Shelf life (days): 1460
CAS Number: 498-36-2
Notes: 2-Hydroxyisocaproic acid is a metabolite of L-leucine (Item No. 34342) catabolism.{68286,68287,68288,68289,68290} It is formed from L-leucine via an α-ketoisocaproic acid (Item Nos. 34749 / 21052) intermediate by hydroxyisocaproic acid dehydrogenase in L. lactis.{68286} 2-Hydroxyisocaproic acid is active against a variety of Gram-positive and -negative bacteria (IC50s = 0.6-4.5 mg/ml) and several Candida species (IC50s = 18-36 mg/ml).{68287,68288} Dietary administration of 2-hydroxyisocaproic acid (50.4 g/kg) also prevents reductions in protein synthesis during the immobilization period and increases protein synthesis and muscle mass during the recovery period in casted animals in a rat model of immobilization-induced muscle atrophy.{68289}
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