Formulation: A crystalline solid
Formal Name: [3aS-(3aα,4β,6aα)]-2-amino-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazole-4-pentanoic acid, monohydrobromide
Purity: ≥98%
Formula Markup: C10H17N3O2S • HBr
Formula Weight: 324,2
Shelf life (days): 1460
CAS Number: 76985-52-9
Notes: 2-Iminobiotin is a guanidine-modified derivative of the carboxylase coenzyme biotin (Item No. 22582) and an inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Kis = 21.8 and 37.5 µM for the mouse and rat enzymes, respectively).{32524} It has been used to label and selectively retrieve sialoglycoproteins from erythrocyte ghosts.{32523} 2-Iminobiotin (0.2 mg/kg every four hours) prevents hypoxia-ischemia-induced decreases in brain phosphocreatine and ATP levels and increases in edema in the parietal cortex and striatum, as well as reduces apoptosis in the parietal- and temporal cortex and striatum, in piglets.{67363} It increases survival of, and decreases electrographic seizures in, hypoxia-ischemia-injured piglets when administered at doses of 0.2 and 1 mg/kg every four hours.{67364} Lipid nanoparticles (LNPs) containing 2-iminobiotin conjugated to poly-L-lysine have been used to improve LNP tumor targeting, uptake, and retention compared with LNPs containing biotin conjugated to poly-L-lysine in rats.{67362}
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