Formulation: A solid
Formal Name: 3-hydroxy-benzenepropanoic acid
Purity: ≥98%
Formula Markup: C9H10O3
Formula Weight: 166,2
Shelf life (days): 1460
CAS Number: 621-54-5
Notes: 3-(3-Hydroxyphenyl)propanoic acid is an active metabolite of various polyphenols, including dihydrocaffeic acid (Item No. 28390) and chlorogenic acid (Item No. 70930).{64828,64829} It is formed from these polyphenols by gut microbiota.{64828,64830} It reduces bone resorption activity and the number of RANKL-differentiated RAW 264.7 osteoclasts in a hydroxyapatite model of resorption when used at a concentration of 0.1 mg/ml.{64831} 3-(3-Hydroxyphenyl)propanoic acid inhibits amyloid-β (1-42) (Aβ42) peptide aggregation in a cell-free assay when used at a concentration of 100 µM and accumulates in the brain of rats fed grape seed polyphenol extract.{64830} It also reduces hemolysis, restores disruptions to membrane integrity, and reverses increases in malondialdehyde (MDA) activity and decreases in catalase (CAT) and superoxide dismutase (SOD) activities induced by cadmium in isolated rat erythrocytes when used at a concentration of 500 nM and in rat erythrocytes ex vivo after administration of an 80 mg/kg dose.{64829} It also prevents increases in intracellular cadmium levels in these in the same cells in vitro and in vivo.
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