Formulation: A solid
Formal Name: 5-phenyl-1H-indole-3-acetic acid
Purity: ≥95%
Formula Markup: C16H13NO2
Formula Weight: 251,3
Shelf life (days): 1460
CAS Number: 168649-23-8
Notes: 5-Ph-IAA is a phenylic substituted indole and ligand used for bump and hole, a technique used to study single protein isoforms when familial homology would interfere with other isoform-selective approaches.{65606,65607} It activates a bump-and-hole-modified protein, transport inhibitor response 1 (TIR1), which forms a PROTAC-associated complex that targets and degrades sister chromatid cohesion 1 (RAD21) and induces cell cycle arrest at the G2 or M phase in Arabidopsis when used at a concentration of 1 µM.{65607} Intraperitoneal administration of 5-Ph-IAA (1, 3, or 10 mg/kg per day) reduces tumor growth via the same process by targeting and degrading bromodomain-containing protein 4 (BRD4) in an HCT116 colorectal cancer xenograft mouse model.
English
Deutsch
