Formulation: A solid
Formal Name: (5α)-3β-hydroxy-d4-cholan-24-oic acid
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C24H36D4O3
Formula Weight: 380,6
Shelf life (days): 1460
CAS Number: 2410277-60-8
Notes: Alloisolithocholic acid-d4 is intended for use as an internal standard for the quantification of alloisolithocholic acid (Item No. 29542) by GC- or LC-MS. Alloisolithocholic acid is a metabolite of the secondary bile acid metabolite 3-oxo lithocholic acid (dehydrolithocholic acid; Item No. 29544).{62987} It is formed from 3-oxo lithocholic acid by gut microbiota.{62987} Alloisolithocholic acid (20 µM) increases the association of the nuclear hormone receptor nerve growth factor IB (Nr4a1) to the gene encoding forkhead box protein P3 (Foxp3) in isolated mouse CD4+ T cells. It induces the differentiation of isolated mouse T cells into regulatory T cells (Tregs) and the production of mitochondrial reactive oxygen species (ROS) in isolated mouse CD4+ T cells when used at a concentration of 20 µM.{53583} Alloisolithocholic acid (6 mg/kg) reduces hepatic bile flow and bile salt, cholesterol, and phospholipid secretion, as well as induces loss of microvilli and dilation of canaliculi in hepatocytes, markers of cholestasis, in rats.{53939} Fecal levels of alloisolithocholic acid are reduced in patients with Crohn’s disease or ulcerative colitis.{62987}
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