Formulation: A solid
Formal Name: N-[(2R)-2-hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidoyl chloride, 1-oxide
Purity: ≥98%
Formula Markup: C14H20ClN3O3
Formula Weight: 313,8
Shelf life (days): 1460
CAS Number: 289893-25-0
Notes: Arimoclomol is a co-inducer of heat shock proteins (Hsps).{69148,69149} It increases pancreatic Hsp60 and Hsp70 levels, decreases malondialdehyde (MDA) and protein carbonyl levels, increases glutathione peroxidase (GPX) activity, and decreases Cu/Zn superoxide dismutase (SOD) activity in a rat model of cholecystokinin (CCK) octapeptide-induced acute pancreatitis when administered at a dose of 20 mg/kg.{69148} Arimoclomol (10 mg/kg, i.p.) increases spinal cord levels of Hsp70 and Hsp90 and motoneuron survival, decreases disease severity, and increases lifespan in a Cu/Zn SOD mutant (SOD1G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS).{69149}
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