Betaxolol-d7 (hydrochloride), CAS 1219802-92-2

Formulation: A solid

Formal Name: 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-((propan-2-yl-d7)amino)propan-2-ol, monohydrochloride

Purity: ≥99% deuterated forms (d1-d7)

Formula Markup: C18H22D7NO3 • HCl

Formula Weight: 350,9

Shelf life (days): 1460

CAS Number: 1219802-92-2

Notes: Betaxolol-d7 is intended for use as an internal standard for the quantification of betaxolol (Item No. 18625) by GC- or LC-MS. Betaxolol is an antagonist of the β1-adrenergic receptor (β1-AR; Ki = 23 nM).{39508} It is selective for the β1-AR over the β2-AR (Ki = 790 nM). Betaxolol is cytotoxic to 10.014 pRSV-T human corneal epithelial cells.{30089} It reduces intraocular pressure in cynomolgus monkeys with ocular hypertension induced by laser trabeculoplasty when administered at a dose of 150 µg/animal.{58318} Betaxolol also inhibits sodium influx induced by the neurotoxin veratridine in rat cortical synaptosomes (IC50 = 28.3 µM).{30086}

• SKU: CAY39815-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39815-500
• Package Unit: 500 µg
• Quantity Unit: STK
• Application: GC-MS, LC-MS, Isotopenmarkierung