Formulation: 20 mM Tris, pH 8.0, 0.2 M sodium chloride and 5 mM calcium chloride
Purity: ≥90% estimated by SDS-PAGE
Shelf life (days): 365
Notes: C-Reactive protein (CRP) is an acute phase protein and a member of the pentraxin family.{15269} It is composed of five protomers arranged symmetrically around a central pore and is primarily expressed in, and secreted by, the liver. CRP modulates endothelial function, increases protein levels of intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin, stimulates coagulation, mediates uptake of LDL into macrophages, and destabilizes atherosclerotic plaques.{15269,15777,15778,10506,15270} In addition, CRP binds to phosphocholine on microbes in a calcium-dependent manner, acts as a ligand for receptors on phagocytic leukocytes, mediates activation of monocytes and macrophages via IL-6 and other cytokines, and assists in the complement pathway.{15269,15774,15775} CRP plasma levels increase in response to acute and chronic inflammatory conditions, and high plasma CRP concentrations are associated with an increased risk for atherosclerosis.{15269,15307} Cayman’s C-Reactive Protein (human, recombinant) protein consists of 206 amino acids, has a calculated molecular weight of 23 kDa, and a predicted N-terminus of Gln19 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 26 kDa due to glycosylation.
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