Formulation: A solid
Formal Name: 1-[(2-chlorophenyl)methyl]-5′-phenyl-spiro[3H-indole-3,2′(3′H)-[1,3,4]thiadiazol]-2(1H)-one
Purity: ≥98%
Formula Markup: C22H16ClN3OS
Formula Weight: 405,9
Shelf life (days): 1460
CAS Number: 331458-02-7
Notes: CFM 4 is an inhibitor of the protein-protein interaction between anaphase-promoting complex subunit 2 (APC2) and cell cycle and apoptosis regulatory protein 1 (CARP-1).{66366} It inhibits the binding of APC2 to CARP-1 (IC50 = 0.75 µM). CFM 4 reduces the proliferation of a variety of breast, prostate, and colon cancer cells in a concentration-dependent manner. It induces cell cycle arrest at the G0 phase in MDA-MB-468 breast cancer cells and apoptosis in T47D breast cancer cells when used at a concentration of 20 µM. Nanostructure lipid carrier-encapsulated CFM 4 (40 mg/kg every other day) reduces tumor growth in an A549 non-small cell lung cancer (NSCLC) mouse xenograft model.{66367}
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