Formulation: A solution in methyl acetate
Formal Name: (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl (9Z,12Z)-octadeca-9,12-dienoate-14,14,15,15,16,16,17,17,18,18,18-d11
Purity: ≥99% deuterated forms (d1-d11)
Formula Markup: C45H65D11O2
Formula Weight: 660,2
Shelf life (days): 730
Notes: Cholesteryl linoleate-d11 is intended for use as an internal standard for the quantification of cholesteryl linoleate (Item No. 22597) by GC- or LC-MS. Cholesteryl linoleate is a pro-atherogenic cholesterol ester.{38440,38441} It has been found in the plasma membrane of macrophages as a component of LDL, where it undergoes oxidation to form cholesteryl linoleate hydroperoxides (Item No. 48001).{38440} Cholesteryl linoleate levels are increased in apoB-lipoproteins and positively correlated with hepatic cholesterol levels and the number of atherosclerotic lesions in transgenic mice overexpressing human ABCA1.{38441} Lipoprotein levels of cholesteryl linoleate are increased and associated with lipid radical formation in patients with β-thalassemia.{67248}
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