Formulation: A solid
Formal Name: 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-d3-1-propanamine, monohydrochloride
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C20H15D6N • HCl
Formula Weight: 317,9
Shelf life (days): 1460
CAS Number: 2748492-38-6
Notes: Cyclobenzaprine-d6 is intended for use as an internal standard for the quantification of cyclobenzaprine by GC- or LC-MS. Cyclobenzaprine is a skeletal muscle relaxant.{25917,25918,25919} It is an antagonist of M1, M2, and M3 muscarinic acetylcholine receptors (mAChRs; Kis = 25, 60, and 6 nM, respectively), the histamine H1 receptor (IC50 = 20 nM), and serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2B, and 5-HT2C (Kis = 1,685, 330, and 56 nM, respectively). Cyclobenzaprine (1 mg/kg) prevents increases in the flexor reflex induced by the 5-HT2 receptor agonist DOI in spinalized rats.{25919} Formulations containing cyclobenzaprine have been used as muscle relaxants.
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