Formulation: A solid
Formal Name: N,N-dimethyl-α3-[2-(1-naphthalenyloxy)ethyl-d7]-benzenemethanamine, monohydrochloride
Purity: ≥95%
Formula Markup: C21H16D7NO • HCl
Formula Weight: 348,9
Shelf life (days): 1460
CAS Number: 2699607-47-9
Notes: Dapoxetine-d7 is intended for use as an internal standard for the quantification of dapoxetine by GC- or LC-MS. Dapoxetine is a selective serotonin (5-HT) reuptake inhibitor (SSRI; IC50 = 10 nM in isolated rat cerebral cortex membranes).{65667} It selectively inhibits 5-HT uptake over norepinephrine or dopamine uptake in cells expressing the human transporters (IC50s = 1.2, 202, and 1,720 nM, respectively).{65668} (S)-Dapoxetine (1 and 80 µg/animal) increases the amplitude of the pudendal motoneuron reflex discharges in a rat model of the ejaculatory expulsion reflex induced by electrical stimulation of the dorsal penis nerves.{69729} It decreases infarct volume and improves motor performance in a rat model of ischemic stroke induced by bilateral common carotid artery occlusion when administered at doses of 30 or 60 mg/kg.{69730} Dapoxetine (5 mg/kg) decreases prostate weight and levels of Tnf-α, inducible nitric oxide synthase (iNos), and Cox-2 in a rat model of testosterone propionate-induced benign prostatic hyperplasia (BPH).{69731} Formulations containing dapoxetine have been used in the treatment of premature ejaculation.
English
Deutsch
