Formulation: A solid
Formal Name: α-(aminomethyl)-2,5-dimethoxy-benzenemethanol
Purity: ≥98%
Formula Markup: C10H15NO3
Formula Weight: 197,2
Shelf life (days): 1460
CAS Number: 3600-87-1
Notes: Desglymidodrine is the active metabolite of the prodrug midodrine (Item No. 17349).{62783} It is formed from midodrine by enzymatic hydrolysis.{62246} Desglymidodrine is an agonist of α1-adrenergic receptors (α1-ARs).{62783} It binds to α1-ARs (Kis = 9.77, 9.55, and 8.51 µM for α1A, α1B, and α1D-ARs, respectively) and increases intraurethral pressure (IUP) and mean arterial pressure (MAP) by 5 and 20 mm Hg, respectively, in anesthetized dogs at doses of 205 and 250 nmol/kg, respectively.