Formulation: A solid
Formal Name: (2S,3S)-3-(acetyloxy-d3)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one, monohydrochloride
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C22H23D3N2O4S • HCl
Formula Weight: 454
Shelf life (days): 1460
CAS Number: 1217860-13-3
Notes: Diltiazem-d3 is intended for use as an internal standard for the quantification of diltiazem by GC- or LC-MS. Diltiazem is an L-type calcium channel inhibitor.{72255,72256} It inhibits stretch-induced calcium release in H9c2 rat cardiomyocytes when used at concentrations ranging from 10-1,000 µM.{72255} In vivo, diltiazem (100 mg/kg) inhibits angiotensin II-induced increases in systolic blood pressure and aortic aneurysm formation in ApoE-/- mice.{72256} It reduces myocardial apoptosis, increases blood flow in ischemic myocardium, and reduces arrhythmias in a dog model of ischemia and reperfusion-induced myocardial infarction.{72257} Formulations containing diltiazem have been used in the treatment of hypertension and angina.
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