Formulation: A solid
Formal Name: 2-[[(3S)-3-[[(2R,3S)-3-amino-2-methyl-1-oxooctyl]amino]-1-oxooctyl]amino]-2-butenoic acid, monohydrochloride
Purity: ≥90%
Formula Markup: C21H39N3O4 • HCl
Formula Weight: 434
Shelf life (days): 1460
Notes: Dioctatin A is a bacterial metabolite that has been found in Streptomyces and has mycotoxin inhibitory activity.{62989} It inhibits the production of aflatoxin and norsolorinic acid, a biosynthetic precursor of aflatoxin, in A. parasiticus (IC50s = 4 and 0.8 µM, respectively) but does not inhibit mycelial growth of A. parasiticus when used at a concentration of 50 µM. Dioctatin A (50 µM) decreases the mRNA expression of genes encoding aflatoxin biosynthetic enzymes and increases the production of the fungal metabolite kojic acid (Item No. 22712) in A. parasiticus. It inhibits the production of the mycotoxin sterigmatocystin (Item No. 11441) in A. nidulans (IC50 = 0.3 µM) and the conidiation of A. parasiticus and A. nidulans when used at a concentration of 50 µM.
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