Formulation: A solid
Formal Name: 9-(ethoxyimino)-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile
Purity: ≥95% (mixture of cis/trans isomers)
Formula Markup: C15H9N5O
Formula Weight: 275,3
Shelf life (days): 1460
CAS Number: 924296-19-5
Notes: DUBs-IN-2 is an inhibitor of ubiquitin-specific protease 8 (USP8; IC50 = 280 nM).{62998} It is selective for USP8 over USP7 (IC50 = >100 µM). DUBs-IN-2 increases the level of programmed cell death protein ligand 1 (PD-L1) in H460 cells when used at a concentration of 2 µM and PC-9 cells at 2 and 4 µM.{51220} Intraperitoneal injection of DUBs-IN-2 (1 mg/kg every other day), in combination with an anti-PD-L1 antibody and paclitaxel (Item No. 10461), decreases tumor weight, tumor size, and lung metastasis and increases CD8+ T cell numbers within the primary tumor in a 4T1 murine mammary carcinoma model.{62999}
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