Notes: Furosine is an L-lysine (Item No. 36455) derivative formed by the Maillard reaction and a marker of overheating in foods.{66354} It induces cell cycle arrest at the S phase in HEK293 and HepG2 cells when used at a concentration of 200 µM.{66357} Furosine (500 mg/kg per day) increases testicular atrophy and decreases testosterone levels in mice.{66355} Fingernail levels of furosine are increased in patients with diabetes mellitus.{66356} It has been found in high-temperature milk and microwaved cookies.{66354}