Fz25, CAS 2762498-70-2

Formulation: A solid

Formal Name: (17β)-3-(phenylmethoxy)-17-(1H-1,2,3-triazol-5-yl)-estra-1,3,5(10)-trien-17-ol

Purity: ≥98%

Formula Markup: C27H31N3O2

Formula Weight: 429,6

Shelf life (days): 730

CAS Number: 2762498-70-2

Notes: Fz25 is a triazole-modified sterol and an anticancer agent.{65665} It inhibits the proliferation of A2780 ovarian and HT-29 colorectal cancer cells (IC50s = 15.29 and 15.98 µM, respectively). Fz25 decreases the phosphorylation of EGFR and STAT3 in A2780 cells when used at a concentration of 30.58 µM and phosphorylation of ERK, STAT3, and mammalian target of rapamycin (mTOR) in HT-29 cells at 31.96 µM. It reduces the efflux activity of P-glycoprotein (P-gp), also known as multidrug resistance protein 1 (MDR1), in a reporter assay using HEK293 cells when used at a concentration of 10 µM.

• SKU: CAY37752-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 37752-50
• Package Unit: 50 mg
• Quantity Unit: STK
• Application: Reinstoffe