HM43239, CAS 2294874-49-8

Formulation: A solid

Formal Name: rel-5-chloro-N-[3-cyclopropyl-5-[[(3R,5S)-3,5-dimethyl-1-piperazinyl]methyl]phenyl]-4-(6-methyl-1H-indol-3-yl)-2-pyrimidinamine

Purity: ≥98%

Formula Markup: C29H33ClN6

Formula Weight: 501,1

Shelf life (days): 1460

CAS Number: 2294874-49-8

Notes: HM43239 is an inhibitor of wild-type (WT) and internal tandem duplication (ITD) mutant FMS-related tyrosine kinase 3 (FLT3; IC50s = 1.1 and 1.8 nM, respectively).{69381} It also inhibits VEGFR2 and spleen tyrosine kinase (Syk) by 100 and 95%, respectively, when used at a concentration of 100 nM. HM43239 inhibits the growth of MOLM-13 and MV4-11 leukemia cells (GI50s = 5.2 and 1.3 nM, respectively).

• SKU: CAY37737-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 37737-25
• Package Unit: 25 mg
• Quantity Unit: STK
• Application: Reinstoffe