Formulation: A solid
Formal Name: 3,4-dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide
Purity: ≥98%
Formula Markup: C18H17N3O3
Formula Weight: 323,4
Shelf life (days): 1460
CAS Number: 942655-44-9
Notes: JK-P3 is an inhibitor of the tyrosine kinases VEGFR2, FGFR1, and FGFR3 (IC50s = 7.83, 27, and 5.18 µM, respectively).{69298} It decreases VEGF-A-induced VEGFR2 phosphorylation in human umbilical vein endothelial cells (HUVECs) when used at a concentration 10 µM. JK-P3 decreases the proliferation of HCT116, SW480, and HT-29 colon cancer cells (IC50s = 24.26, 27.2, and 29.65 µM, respectively), as well as A549 lung cancer cells (IC50 = 30.49 µM).{69299} It decreases wound closure percentage in a scratch assay, as well as endothelial branch length and branch points formed by VEGF-A-stimulated HUVECs when used at a concentration of 10 µM.{69298}
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