Formulation: A neat oil
Formal Name: 3,7-dimethyl-1,6-octadien-1,1,2-d3-3-ol
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C10H15D3O
Formula Weight: 157,3
Shelf life (days): 1460
CAS Number: 1216673-02-7
Notes: (±)-Linalool-d3 is intended for use as an internal standard for the quantification of (±)-linalool (Item No. 21575) by GC- or LC-MS. (±)-Linalool is a monoterpene alcohol that has been found in C. sativa, C. indica, and hemp with diverse biological activities.{41453,21575,36770,36771,36772,42327} It induces cell cycle arrest at the G0/G1 and G2M phase in U937 and HeLa cells, respectively.{21575} (±)-Linalool is cytotoxic to U937 and HeLa cells (IC50s = 2.59 and 11.02 μM, respectively). It induces recruitment of a PGC-1α coactivator peptide to the PPARα ligand binding domain (EC50 = 5.45 μM in a TR-FRET assay).{36770} In vivo, (±)-linalool reduces plasma triglyceride concentration in mice fed a Western diet and transgenic mice expressing human ApoE2, but not PPARα-/- mice. It has molluscicidal and larvicidal effects in vitro (LC50s = 0.25 and 0.07 mg/L for O. hupensis and S. japonicium, respectively), and it reduces the amount of schistosomulum recovered from mouse skin after S. japonicium challenge infection.{36771} (±)-Linalool (10-40 mg/kg) reduces the number of macrophages and neutrophils, as well as the production of TNF-α, IL-6, IL-1β, IL-8, and MCP-1, in bronchoalveolar lavage fluid (BALF) in a mouse model of cigarette smoke-induced acute lung inflammation.{36772} It also decreases immobility time in the forced swim test in mice, indicating antidepressant-like activity.{42327}
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