Formulation: A solid
Formal Name: 9-(1-methylethyl)-N-[[3-(trifluoromethyl)phenyl]methyl]-9H-purin-6-amine
Purity: ≥98%
Formula Markup: C16H16F3N5
Formula Weight: 335,3
Shelf life (days): 1460
CAS Number: 1353867-91-0
Notes: Longdaysin is an inhibitor of casein kinase 1δ (CK1δ) and CK1α (IC50 = 12 µM for both).{68349} It also inhibits cyclin-dependent kinase 2 (Cdk2), Cdk7, MAPK, and MAP3K (IC50s = 13, 32, 59, and 92 µM, respectively). Longdaysin increases the circadian period of U2OS cells by one and five hours when used at concentrations of 0.39 and 3.4 µM, respectively.{38350} It inhibits Wnt-signaling induced by Wnt3A-containing conditioned medium in HEK293 cells and reduces levels of active β-catenin in HEK293 cells expressing CK1δ or CK1ε. Longdaysin (10 and 25 µM) reduces colony formation, as well as cell migration and invasion, by Hs 578T and MDA-MB-231 breast cancer cells. In vivo, longdaysin (5 mg/kg) reduces tumor volume in an MDA-MB-231 mouse xenograft model.
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