Formulation: A solid
Formal Name: 4-[3-(2-methoxy-3-pyridinyl)pyrazolo[1,5-a]pyrimidin-5-yl]-1-piperazinecarboxylic acid, 1-methylethyl ester
Purity: ≥98%
Formula Markup: C20H24N6O3
Formula Weight: 396,4
Shelf life (days): 1460
CAS Number: 1454555-29-3
Notes: LP-935509 is an inhibitor of AP2-associated protein kinase 1 (AAK1) and BMP2-inducible kinase (BIKe; IC50s = 3.3 and 14 nM, respectively).{51266} It is selective for AAK1 and BIKe over μ- and κ-opioid, as well as α2A- and α2C-adrenergic, receptors (IC50s = >30 µM for all), α1 and α2 subunit-containing GABAA receptors (IC50s = 12 µM for both), and cyclin G-associated kinase (GAK; IC50 = 0.32 µM). LP-935509 (1 µM) reduces phosphorylation of the synaptic vesicle regulator AP2 complex subunit Μu-1 (AP2M1) in SH-SY5Y neuroblastoma cells.{51267} It reduces the number of formalin-induced flinches in mice when administered at doses of 10, 30, and 60 mg/kg.{51266}
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