Formulation: A solid
Formal Name: (3β,22α,25R)-26-(β-D-glucopyranosyloxy)-22-methoxyfurost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-β-D-glucopyranoside
Purity: ≥98%
Formula Markup: C52H86O22
Formula Weight: 1063,2
Shelf life (days): 1460
CAS Number: 54522-52-0
Notes: Methylprotodioscin is a steroidal saponin that has been found in A. cochinchinensis and has diverse biological activities.{66285,66286,66287} It suppresses mucin 5AC (MUC5AC) production induced by EGF or phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in H292 cells when used at a concentration of 1 µM.{66285} Methylprotodioscin inhibits the proliferation of HeLa cervical cancer cells (IC50 = 18.31 µM) but has no effect on non-cancerous HEK293 cells.{66286} It also induces production of reactive oxygen species (ROS), apoptosis, and cell cycle arrest at the G2/M phase in HeLa cells. In vivo, methylprotodioscin (50 mg/kg) decreases bone loss and prevents decreases in bone mineral content and bone mineral density in a mouse model of ovariectomy-induced osteoporosis.{66287}
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