Formulation: A crystalline solid
Formal Name: 5-(methylamino)-2-(1-naphthalenyl)-4-oxazolecarbonitrile
Purity: ≥98%
Formula Markup: C15H11N3O
Formula Weight: 249,3
Shelf life (days): 1460
CAS Number: 847163-28-4
Notes: Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides.{3140} The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer.{12192} ML-351 is an inhibitor of human reticulocyte 15-LO-1 (IC50 = 200 nM) with >250-fold selectivity over the related enzymes 5-LO, platelet 12-LO, 15-LO-2, ovine COX-1, and human COX-2.{29406,26085} ML-351 was shown to be protective against oxidative glutamate toxicity in mouse neuronal HT-22 cells and significantly reduced infarct size in an in vivo mouse model for ischemic stroke.{29406,26085}
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