Formulation: A solid
Formal Name: 3-[[(4-methylphenyl)sulfonyl]amino]-benzoic acid, methyl ester
Purity: ≥98%
Formula Markup: C15H15NO4S
Formula Weight: 305,3
Shelf life (days): 1460
CAS Number: 173436-66-3
Notes: MSAB is an inhibitor of Wnt/β-catenin signaling.{64960} It binds to β-catenin and promotes its proteasomal degradation in HCT116 cells. MSAB (2-10 µM) selectively inhibits the proliferation of Wnt-dependent cancer cells over non-cancerous cells and Wnt-independent cancer cells. It reduces Wnt3a-induced increases in β-catenin levels in a reporter assay using HEK293T cells. MSAB decreases the expression of the Wnt target genes AXIN2, MYC, CCND1, and BMP4 in a concentration-dependent manner in HCT116 cells. It reduces tumor growth and increases intratumoral apoptosis in Wnt-dependent HCT116, HT115, and H23 mouse xenograft models when administered at doses of 10 and 20 mg/kg.
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