N6-Benzyladenosine-5'-O-diphosphate (sodium salt)

Formulation: A solution in water

Formal Name: ((2R,3S,4R,5R)-5-(6-(benzylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl diphosphate, trisodium salt

Purity: ≥95%

Formula Markup: C17H18N5O10P2 • 3Na

Formula Weight: 583,3

Shelf life (days): 730

Notes: N6-Benzyladenosine-5'-O-diphosphate is a derivative of ADP (Item Nos. 16778 / 21121) and an active metabolite of the cytokinin N6-benzyladenine (Item No. 21711).{69294,69295,69296} It inhibits the ATPase activities of mortalin, heat shock protein 70 (Hsp70), and heat shock cognate 71 kDa protein (Hsc70; apparent Kis = 86.51, 294.5, and 1,612 µM, respectively, for the human enzymes).{69295} N6-Benzyladenosine-5'-O-diphosphate inhibits the proliferation of CEM, HL-60, and K562 leukemia, RPMI-8226 multiple myeloma, and MCF-7 breast cancer cells (IC50s = 2, 1.3, 4, 4.5, and 8 µM, respectively).{69296} It has also been used in the synthesis of radiolabeled and unlabeled forms of N6-benzyladenosine 5'-(γ-thio)-triphosphate (N6-benzyl-ATPγS), which have been used to determine kinase activity.{69297,34226}

• SKU: CAY38370
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 38370-2.6
• Green Labware: No
• Package Unit: 2,6 mg
• Quantity Unit: STK
• Application: Reinstoffe