Formulation: A solid
Formal Name: 6-[(2R,3S)-3-[[[(4-chloro-2-methylphenyl)sulfonyl]amino]methyl]bicyclo[2.2.2]oct-2-yl]-5Z-hexenoic acid, dicyclohexylamine salt
Purity: ≥98%
Formula Markup: C22H30ClNO4S • C12H23N
Formula Weight: 621,3
Shelf life (days): 1460
Notes: ONO-8711 is an antagonist of the prostaglandin E2 (PGE2; Item No. 14010) receptor subtype EP1 (Kis = 0.6 and 1.7 nM for human and mouse receptors, respectively, expressed in CHO cells).{7415} It is selective for EP1 over EP2, EP3, and EP4 (Kis = >1,000, 67, and >1,000 nM, respectively, for mouse receptors expressed in CHO cells). ONO-8711 inhibits PGE2-induced increases in intracellular calcium concentrations in cells expressing human or mouse EP1 (EC50s = 50 and 210 nM, respectively). Dietary administration of ONO-8711 (400 and 800 ppm) reduces the incidence of squamous cell carcinoma and severe dysplasia in a rat model of tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.{19682}
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