Formulation: A solid
Formal Name: (R)-142-oxo-2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80,83,86,89,92,95,98,101,104,107,110,113,116,119,122,125,128,131,134,137,143-heptatetracontaoxa-141-azahexatetracontahectane-145,146-diyl ditetradecanoate
Purity: ≥95%
Formula Markup: C126H249NO52
Formula Weight: 2610,3
Shelf life (days): 1460
Notes: PEG(2000)-C-DMG is a PEGylated derivative of 1,2-dimyristoyl-sn-glycerol (1,2-DMG; Item No. 15077).{64813} It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of siRNA. LNPs containing PEG(2000)-C-DMG and encapsulating siRNA targeting the genes encoding programmed cell death protein ligand 1 (PD-L1) and PD-L2 decrease PD-L1 and PD-L2 levels in monocyte-derived dendritic cells. Formulations containing PEG(2000)-C-DMG have been used in the development of LNPs for the delivery of siRNA-based vaccines.
English
Deutsch
