Formulation: A solution in ethanol
Formal Name: 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-1-octanesulfonic acid
Purity: ≥95%
Formula Markup: C8HF17O3S
Formula Weight: 500,1
Shelf life (days): 730
CAS Number: 1763-23-1
Notes: Perfluorooctanesulfonic acid (PFOS) is a perfluoroalkyl substance (PFAS).{49177} It decreases peroxisome proliferator-activated receptor γ (PPARγ) transactivation in a reporter assay and induces apoptosis in NRK-52E rat renal proximal tubular epithelial cells, effects that can be reversed by the PPARγ agonist rosiglitazone (Item Nos. 71740 / 11884 / 71742), when used at a concentration of 50 nM. PFOS (20 mg/L) increases malondialdehyde (MDA) levels and decreases glutathione (GSH) levels in zebrafish larvae.{67212} It decreases body weight and induces hepatomegaly, renal hypertrophy, neoplastic growth in the gonads, thickening of pulmonary epithelial walls, and focal hyperplasia of cerebral gliocytes in rats when administered at a dose of 20 mg/kg.{65446} Maternal serum exposure to PFOS is positively associated with gestational diabetes, and umbilical cord serum levels are negatively associated with infant birth weight and head circumference.{68230,55623} It has been found in lake trout (S. namaycush), marine mammals, and urban watersheds.{61887,65487,62844}
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