PF-249, CAS 1467059-70-6

Formulation: A solid

Formal Name: 6-chloro-5-[6-(dimethylamino)-2-methoxy-3-pyridinyl]-1H-indole-3-carboxylic acid

Purity: ≥98%

Formula Markup: C17H16ClN3O3

Formula Weight: 345,8

Shelf life (days): 1460

CAS Number: 1467059-70-6

Notes: PF-249 is an allosteric activator of AMP-activated protein kinase β1 (AMPKβ1) heterotrimers (EC50s = 8 and 6 nM for human AMPK α1β1γ1 and -α2β1γ1, respectively).{64966,64965} It is selective for AMPK α1β1γ1 and -α2β1γ1 over AMPK α1β2γ1, -α2β2γ1, and -α2β2γ3 at 40 µM and a panel of receptors, channels, and phosphodiesterases at 10 µM.{64966,64965} PF-249 decreases proteinuria and improves kidney function in an obese ZSF1 rat model of diabetic nephropathy in a dose-dependent manner.{64966}

• SKU: CAY38416-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 38416-25
• Package Unit: 25 mg
• Quantity Unit: STK
• Application: Reinstoffe