Formulation: A solid
Formal Name: (8S,10S)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[(1S,3R,4aS,9S,9aR,10aS)-octahydro-9-methoxy-1-methyl-1H-pyrano[4′,3′:4,5]oxazolo[2,3-c][1,4]oxazin-3-yl]oxy]-5,12-naphthacenedione
Purity: ≥95%
Formula Markup: C32H35NO13
Formula Weight: 641,6
Shelf life (days): 1460
CAS Number: 202350-68-3
Notes: PNU 159682 is an anthracycline and active metabolite of the anticancer agent nemorubicin.{68371} It is formed from nemorubicin by the cytochrome P450 (CYP) isoform CYP3A4. PNU 159682 forms DNA adducts and inhibits the proliferation of several cancer cell lines (IC70s = 0.075-0.577 nM).{68372,68371} It reduces tumor volume in an MX-1 breast cancer mouse xenograft model when administered at a dose of 4 µg/kg.{68371} PNU 159682 has also been used in the synthesis of cytotoxic payload moieties of antibody-drug conjugates (ADCs).{68373}
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