Formulation: A solid
Formal Name: N,N,α-trimethyl-10H-phenothiazine-10-ethanamine-d4, monohydrochloride
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C17H16D4N2S • HCl
Formula Weight: 324,9
Shelf life (days): 1460
CAS Number: 1173018-74-0
Notes: Promethazine-d4 is intended for use as an internal standard for the quantification of promethazine (Item No. 16478) by GC- or LC-MS. Promethazine is a first-generation histamine H1 receptor antagonist (Ki = 0.98 nM for the human receptor).{40358} It is selective for histamine H1 over H3 and H4 receptors (Kis = >100 and 77.6 µM, respectively, for the human receptors). Promethazine also binds muscarinic acetylcholine receptors (mAChRs; Ki = 22 nM).{23214} It inhibits histamine-induced paw edema and acetic acid-induced writhing in mice (ED50s = 5.9 and 11.8 mg/kg, respectively).{25628} Promethazine (32 mg/kg) decreases the number of motion-induced vomiting episodes in S. murinus.{26898}
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