Formulation: A solid
Formal Name: 5-fluoro-N-[2-[(2S)-1-methyl-2-pyrrolidinyl]ethyl]-3-oxo-6-[3-(2-pyrazinyl)-1-pyrrolidinyl]-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide
Purity: ≥98%
Formula Markup: C35H33FN6O3
Formula Weight: 604,7
Shelf life (days): 1460
CAS Number: 865311-47-3
Notes: Quarfloxin is an inhibitor of RNA polymerase I-mediated transcription.{51352} It binds to G-quadruplex DNA and inhibits the interaction between ribosomal DNA G-quadruplexes and nucleolin, a nucleolar protein required for RNA polymerase I-mediated transcription. Quarfloxin (10 µM) induces nucleolin mislocalization from the nucleoli to the nucleoplasm in A549 cells. It induces apoptosis in A549 and HL-60 cells when used at a concentration of 5 µM. Quarfloxin (5 mg/kg) reduces tumor growth in MDA-MB-231 breast and MiaPaCa-2 pancreatic cancer mouse xenograft models.
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