Formulation: A solid
Formal Name: 6-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[(5,6-dimethyl-2-pyridinyl)amino]-3-pyridazinecarboxamide
Purity: ≥90%
Formula Markup: C18H25N7O
Formula Weight: 355,4
Shelf life (days): 1460
CAS Number: 1446790-62-0
Notes: RO9021 is an inhibitor of spleen tyrosine kinase (Syk; IC50 = 5.6 nM).{64841} It is selective for Syk over a panel of 392 other kinases at 1 µM. RO9021 also inhibits M. tuberculosis serine/threonine protein kinase G (PknG; IC50 = 4.4 µM).{64842} It inhibits the proliferation of, and induces apoptosis in, primary acute myeloid leukemia (AML) cells when used at a concentration of 5 µM.{64843} RO0921 prevents RANKL- and M-CSF-induced osteoclastogenesis in isolated mouse bone marrow-derived macrophages (BMDMs; IC50 = 145 nM).{64841} It reduces disease severity in a mouse model of collagen-induced arthritis when administered at doses of 5 or 45 mg/kg.
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