Formulation: A solution in water
Formal Name: Adenosine, 5′→P′′-ester with [P′′(R)]-thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(O)(OH)(SH)), tetrasodium salt
Purity: ≥95%
Formula Markup: C10H12N5O12P3S • 4Na
Formula Weight: 611,2
Shelf life (days): 730
Notes: Rp-Adenosine-5'-O-(1-thiotriphosphate) (Rp-ATP-α-S) is an isomer of the sulfur-containing nucleotide derivative ATP-α-S and an agonist of the purinergic P2Y1 receptor.{67377} It increases calcium mobilization in HEK293 cells expressing the human P2Y1 receptor (EC50 = 75 nM). Rp-ATP-α-S binds to washed isolated human platelets (Ki = 156 nM), inhibits ADP-induced aggregation of isolated human platelet-rich plasma (PRP; pA2 = 4.74), and inhibits cAMP production induced by prostaglandin E1 (PGE1; Item No. 13010) in isolated human PRP (pA2 = 5.26).{67378,49795} It also induces relaxation of carbamoylcholine-preconstricted guinea pig taenia coli strips (EC50 = 56 nM).{69380} Rp-ATP-α-S has been used in the synthesis of cyclic dinucleotides that are recognized by bacterial riboswitches.{49796}
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