SACLAC, CAS 2248703-42-4

Formulation: A solid

Formal Name: 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-acetamide

Purity: ≥95%

Formula Markup: C20H40ClNO3

Formula Weight: 378

Shelf life (days): 730

CAS Number: 2248703-42-4

Notes: SACLAC is an irreversible inhibitor of acid ceramidase (Ki = 97.1 nM) and a derivative of the acid ceramidase inhibitor SABRAC (Item No. 9003925).{50890} It decreases levels of sphingosine-1-phosphate (S1P) and increases total ceramide levels in OCI-AML-2 acute myeloid leukemia (AML) cells when used at a concentration of 2.5 µM.{64304} SACLAC (10 and 20 µM) induces apoptosis in primary AML cells. It reduces leukemic burden in MV4-11 and U937 AML mouse xenograft models when administered at a dose of 5 mg/kg.

• SKU: CAY9003926-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 9003926-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK
• Application: Reinstoffe